Masunaga Atsuko, Iwamoto Sanju, Nakamura Hisayoshi, Usuda Rhosuke, Masuda Mikio, Suzuki Shuichi, Miyazaki Akira, Suzuki Takashi, Mitsuya Toshiyuki, Yoshitake Tsuyoshi
Department of Surgical Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan.
Pathol Int. 2008 Jun;58(6):402-5. doi: 10.1111/j.1440-1827.2008.02243.x.
Described herein is a case of thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Using immunohistochemical double staining it was found that most of the thymic lymphoid follicles in this case possessed cytokeratin-positive and follicular dendritic cell (FDC) marker-positive cells. Moreover, using immunoelectron microscopy it was confirmed that some of the double-positive cells were thymic epithelial cells. The candidate of cytokeratin subtype expressed on the double-positive cells was cytokeratin 1 (CK1), which was expressed only by the epithelium of Hassall's corpuscles in thymuses from age-matched patients with myasthenia gravis. The present case indicates a possibility that some thymic epithelial cells become FDC, although it was uncertain whether they were derived from the epithelia of Hassall's corpuscles or whether they were at the same differentiation stage as Hassall's corpuscles.
本文描述了一例黏膜相关淋巴组织的胸腺结外边缘区B细胞淋巴瘤。通过免疫组织化学双重染色发现，该病例中的大多数胸腺淋巴滤泡具有细胞角蛋白阳性和滤泡树突状细胞（FDC）标志物阳性细胞。此外，通过免疫电子显微镜证实，部分双阳性细胞为胸腺上皮细胞。双阳性细胞上表达的细胞角蛋白亚型候选物是细胞角蛋白1（CK1），其仅在年龄匹配的重症肌无力患者胸腺中的哈氏小体上皮中表达。本病例表明，一些胸腺上皮细胞有可能成为FDC，尽管尚不确定它们是否源自哈氏小体上皮，也不确定它们是否与哈氏小体处于相同的分化阶段。
