Lanas Angel
Am J Gastroenterol. 2008 May;103(5):1104-5. doi: 10.1111/j.1572-0241.2008.01915.x.
A large number of at-risk patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs) do not receive prophylaxis for gastrointestinal (GI) complications. The combination of a 10-min physician educational intervention and a computer alert has been proved to increase the rate of prescribing gastroprotective therapy for high-risk patients who receive ulcerogenic drugs at hospital discharge from 45% to 67%. This improvement is remarkable; still, more than 30% of these high-risk patients did not receive appropriate therapy. Considering that most patients who receive NSAIDs are outpatients treated by generalists, and considering that adherence may be poor and self-medication with NSAIDs is common among patients with GI risk factors, closing the gap between patients treated with NSAIDs who do and do not receive adequate GI prophylaxis is a challenging endeavor. In order to more effectively pursue this goal, we will need to develop new and more complex approaches.
大量使用非甾体抗炎药（NSAIDs）治疗的高危患者未接受胃肠道（GI）并发症的预防措施。10分钟的医生教育干预与计算机警报相结合，已被证明可将出院时接受致溃疡药物治疗的高危患者开具胃保护疗法的比例从45%提高到67%。这一改善十分显著；然而，仍有超过30%的这些高危患者未接受适当治疗。鉴于大多数接受NSAIDs治疗的患者是由全科医生治疗的门诊患者，且考虑到依从性可能较差，有胃肠道危险因素的患者自行服用NSAIDs的情况很常见，缩小接受NSAIDs治疗且接受和未接受充分胃肠道预防措施的患者之间的差距是一项具有挑战性的工作。为了更有效地实现这一目标，我们将需要开发新的、更复杂的方法。
