Wang Dong, Zhang Shuqun, Chang Zhe, Kong De-Xin, Zuo Zhili
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Nat Prod Bioprospect. 2017 Feb;7(1):113-122. doi: 10.1007/s13659-017-0120-3. Epub 2017 Jan 28.
Recently, there has been a renewed interest in the natural-products-inspired drugs. Quebrachitol (QCT) is one of naturally occurring optically active cyclitols that has now received considerable attention. Until the last decade, it came to be a starting point for the lead discovery. In this review, we had a discussion on the basic research of QCT, including its source, structure, properties, and the recent advances on its application. The biological activities and QCT-inspired leads that are potentially effective for treating human diseases were also discussed.
最近，人们对受天然产物启发的药物重新产生了兴趣。奎布拉醇（QCT）是一种天然存在的旋光性环多元醇，目前已受到广泛关注。直到过去十年，它才成为先导化合物发现的起点。在这篇综述中，我们讨论了QCT的基础研究，包括其来源、结构、性质以及其应用的最新进展。还讨论了其生物活性以及受QCT启发的可能对治疗人类疾病有效的先导化合物。
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