Peppa Melpomeni, Uribarri Jaime, Vlassara Helen
Endocrine Unit, 2nd Dept of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University, Medical School, Athens, Greece.
Hormones (Athens). 2008 Apr-Jun;7(2):123-32. doi: 10.1007/BF03401503.
Aging and related diseases are accompanied by increased Oxidative Stress (OS) and accumulation of Advanced Glycation End products (AGEs). One important component of AGEs accumulation with aging appears to be the sustained exposure to dietary AGE (dAGEs), which contributes to overloading of anti-AGE receptors and depletion of anti-oxidant reserves. In this review, we present experimental animal and human data which support this postulation. Lowering the content of AGEs in the normal diet significantly prevents AGEs accumulation and the increased OS caused by aging and also extends lifespan in mice. In humans, short-term trials indicate that a Low AGEs diet reduces oxidant burden and inflammatory markers. Long-term studies are in progress and will help establish definitive causality between age-related disease states and modern dietary practices in Western societies.
衰老及相关疾病伴随着氧化应激（OS）的增加和晚期糖基化终产物（AGEs）的积累。随着年龄增长，AGEs积累的一个重要因素似乎是持续摄入膳食AGE（dAGEs），这会导致抗AGE受体过载以及抗氧化储备耗竭。在本综述中，我们展示了支持这一假设的实验动物和人类数据。降低正常饮食中的AGEs含量可显著预防AGEs积累以及衰老引起的OS增加，还能延长小鼠寿命。在人类中，短期试验表明低AGEs饮食可减轻氧化负担和炎症标志物。长期研究正在进行中，将有助于确定西方社会中与年龄相关的疾病状态和现代饮食习惯之间的明确因果关系。
