Alger-Mayer S, Rosati C, Polimeni J M, Malone M
Department of Medicine, Division of Gastroenterology and Nutrition, Albany Medical College, MC-23, 47 New Scotland Ave., Albany, NY, 12208, USA.
Department of Surgery, Albany Medical College, Albany, NY, USA.
Obes Surg. 2009 Feb;19(2):139-145. doi: 10.1007/s11695-008-9540-9. Epub 2008 May 14.
The primary purpose of the study was to evaluate the effect of preoperative binge status on long-term weight loss outcomes.
IRB approval was obtained. This prospective study was initiated in 1997 at a large teaching hospital. Adult patients who participated in the study and attended post-surgery clinic visits for at least 12 months were included. Patients completed the gormally binge eating scale (BES), the beck depression inventory (BDI), and the SF-36 at baseline prior to surgery. All data are expressed as mean +/- SD. Data were analyzed using a Student's t test, pairwise correlation and regression analysis as appropriate.
A total of 157 patients (135 women) aged 45 +/- 10 years were recruited. Their preoperative BMI was 50.7 +/- 8.0 kg/m(2). Thirty-seven patients were classified as severe binge eaters (BES >or= 27) prior to surgery. There was no significant difference in their weight loss compared to the rest of the group at any time point up to 6 years after surgery. Patients with significant depressive symptoms (BDI >13) had no significant difference in their weight loss outcomes compared to the rest of the group. Pre-surgery SF-36 scores did not predict differences in weight loss outcome.
Pre-surgical binge status, incidence of depressive symptoms and health related quality of life were not predictive of poor weight loss outcomes in patients up to 6 years after gastric bypass surgery, who were able to make lifestyle changes in preparation for surgery and who adhered to scheduled post surgery clinic visits.
本研究的主要目的是评估术前暴饮暴食状态对长期体重减轻结果的影响。
获得了机构审查委员会（IRB）的批准。这项前瞻性研究于1997年在一家大型教学医院启动。纳入了参与研究并至少进行12个月术后门诊随访的成年患者。患者在手术前基线时完成了习惯性暴饮暴食量表（BES）、贝克抑郁量表（BDI）和SF-36。所有数据均以平均值±标准差表示。根据情况使用学生t检验、成对相关性分析和回归分析对数据进行分析。
共招募了平均年龄为45±10岁的157名患者（135名女性）。他们术前的体重指数（BMI）为50.7±8.0kg/m²。37名患者在手术前被归类为严重暴饮暴食者（BES≥27）。在术后长达6年的任何时间点，与组内其他患者相比，他们的体重减轻情况没有显著差异。有明显抑郁症状（BDI>13）的患者与组内其他患者相比，体重减轻结果没有显著差异。术前SF-36评分不能预测体重减轻结果的差异。
对于能够为手术做出生活方式改变并坚持术后定期门诊随访的患者，在胃旁路手术后长达6年的时间里，术前暴饮暴食状态、抑郁症状发生率和健康相关生活质量并不能预测体重减轻效果不佳。
