Sneyd Mary Jane
Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Cancer Causes Control. 2008 Nov;19(9):993-9. doi: 10.1007/s10552-008-9166-1. Epub 2008 May 14.
To examine disease-specific survival from prostate cancer by ethnic group in New Zealand.
Analyses were based on the 7,733 men with histologically confirmed prostate cancer diagnosed from the start of 1996 to the end of 1999 in New Zealand. Five-year adjusted prostate-specific mortality rates and hazard ratios were calculated for Maori, Pacific, and European men.
In univariate analyses, Maori and Pacific men had higher mortality particularly in the first year after a diagnosis of prostate cancer than did European men. The strongest prognostic factors for prostate cancer were Gleason score and age. When survival analyses by ethnic group were adjusted for age and Gleason score the disparities in survival for Maori men and Pacific men with low-grade prostate cancers remained, with European men having the best survival.
Several possible explanations have been proposed to explain the survival disparities by ethnicity in New Zealand. Differentials in Gleason grade of disease by ethnic group explain a lot of these disparities. Further data on stage of disease at diagnosis, co-morbidity, treatment, access to health services, and behavioral and environmental factors are needed to resolve these issues.
研究新西兰不同种族前列腺癌患者的疾病特异性生存率。
分析基于1996年初至1999年末在新西兰确诊的7733例经组织学证实的前列腺癌男性患者。计算了毛利族、太平洋岛民族和欧洲族男性的五年调整后前列腺特异性死亡率和风险比。
在单因素分析中，毛利族和太平洋岛民族男性的死亡率尤其在前列腺癌诊断后的第一年高于欧洲族男性。前列腺癌最强的预后因素是 Gleason 评分和年龄。当按种族进行生存分析并调整年龄和 Gleason 评分后，低级别前列腺癌的毛利族男性和太平洋岛民族男性的生存差异依然存在，欧洲族男性的生存率最高。
针对新西兰不同种族间生存差异，已提出了几种可能的解释。种族间疾病 Gleason 分级的差异解释了其中许多差异。需要关于诊断时疾病分期、合并症、治疗、获得医疗服务的机会以及行为和环境因素的进一步数据来解决这些问题。
