Schoonderwoerd Bas A, Smit Marcelle D, Pen Lucas, Van Gelder Isabelle C
Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Europace. 2008 Jun;10(6):668-73. doi: 10.1093/europace/eun124. Epub 2008 May 13.
Atrial fibrillation (AF) is a prevalent arrhythmia in patients with cardiovascular disease. The classical risk factors for developing AF include hypertension, valvular disease, (ischaemic) cardiomyopathy, diabetes mellitus, and thyroid disease. In some patients with AF, no underlying (cardiovascular) pathology is present and the aetiology remains unknown. This condition is known as lone AF. However, in recent years, other factors playing a role in the genesis of AF have gained attention, including obesity, sleep apnoea, alcohol abuse and other intoxications, excessive sports practice, latent hypertension, genetic factors, and inflammation. In this review, we address these 'new risk factors' (i.e. as opposed to the classical risk factors) and the mechanisms by which they lead to AF.
心房颤动（AF）是心血管疾病患者中常见的心律失常。发生AF的经典危险因素包括高血压、瓣膜病、（缺血性）心肌病、糖尿病和甲状腺疾病。在一些AF患者中，不存在潜在的（心血管）病理状况，病因仍然不明。这种情况被称为孤立性AF。然而，近年来，在AF发生过程中起作用的其他因素受到了关注，包括肥胖、睡眠呼吸暂停、酒精滥用和其他中毒、过度运动、隐匿性高血压、遗传因素和炎症。在本综述中，我们探讨这些“新危险因素”（即与经典危险因素相对）及其导致AF的机制。
