Rogers M P, Barnett D, Robinson D S
Atherosclerosis. 1976 Sep;24(3):551-64. doi: 10.1016/0021-9150(76)90147-7.
The hydrolysis of an emulsified triglyceride substrate by clearing factor lipase (lipoprotein lipase) normally requires the presence of particular activating polypeptide species. These are present in serum, together with other inhibitory species, as part of the serum lipoproteins. The paper describes a method whereby the net activating ability of individual human sera may be measured routinely. In a normal population, this activating ability is shown to be correlated positively with the fasting serum triglyceride concentration. As the fasting triglyceride concentration increases, there is a rise in the proportion of the total activating ability that is associated with the very low density lipoproteins. A dietary fat load does not raise the total activating ability but does increase the proportion of the total that is associated with the serum lipoproteins of lowest density.
通常情况下，清除因子脂肪酶（脂蛋白脂肪酶）对乳化甘油三酯底物的水解需要特定激活多肽物质的存在。这些物质与其他抑制性物质一起存在于血清中，是血清脂蛋白的一部分。本文描述了一种可常规测量个体人血清净激活能力的方法。在正常人群中，这种激活能力与空腹血清甘油三酯浓度呈正相关。随着空腹甘油三酯浓度的升高，与极低密度脂蛋白相关的总激活能力所占比例会增加。饮食脂肪负荷不会提高总激活能力，但会增加与最低密度血清脂蛋白相关的总激活能力的比例。
