氟硝西泮后的焦虑与睡眠。
Anxiety and sleep after fosazepam.
作者信息
Allen S, Oswald I
出版信息
Br J Clin Pharmacol. 1976 Feb;3(1):165-8. doi: 10.1111/j.1365-2125.1976.tb00584.x.
Abstract
1 Six volunteers of mean age 59 years received placebo for week, then fosazepam (60 mg) nightly for 3 weeks, then placebo for 3 weeks. Subjective ratings and all-night electrophysiological recordings were made. 2 Fosazepam administration improved subjective sleep quality nut impaired feelings of morning vitality. Its withdrawal was associated with anxiety, impaired concentration and continuing impairment of morning vitality. Measured sleep duration increased on fosazepam, sleep was less broken, slow wave sleep stages 3 and 4 diminished in duration and so did REM sleep. 3 Despite the short-life of fosazepam some drug effects persisted for several days after withdrawal, suggesting action of a long half-life metabolite.
摘要
- 6名平均年龄59岁的志愿者先接受了1周的安慰剂治疗，然后每晚服用氟硝西泮（60毫克），持续3周，之后再服用3周安慰剂。同时进行了主观评分和整夜的电生理记录。2. 服用氟硝西泮改善了主观睡眠质量，但损害了早晨的活力感。停药后出现焦虑、注意力不集中以及早晨活力持续受损的情况。服用氟硝西泮时测量的睡眠时间增加，睡眠中断减少，慢波睡眠的3期和4期时长缩短，快速眼动睡眠时长也缩短。3. 尽管氟硝西泮半衰期短，但停药后一些药物作用仍持续了数天，这表明存在半衰期长的代谢产物发挥了作用。
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