硝西泮：疗效持久，但撤药时会有问题。
Nitrazepam: lastingly effective but trouble on withdrawal.
作者信息
Adam K, Adamson L, Brezinová V, Hunter W M
出版信息
Br Med J. 1976 Jun 26;1(6025):1558-60. doi: 10.1136/bmj.1.6025.1558.
Abstract
The sleep of 10 volunteers with an average age of 57 years was recorded electrophysiologically before, during, and after nitrazepam 5 mg nightly for 10 weeks. Sleep was longer and less broken on the drug and no tolerance was obvious after two months' use. Withdrawal of the drug, however, caused sleep to be temporarily worse than before the drug had been taken. Slow-wave sleep was reduced by nitrazepam, but the accompanying secretion of growth hormone was not impaired.
摘要
对10名平均年龄为57岁的志愿者的睡眠情况进行了电生理记录，记录时间为每晚服用5毫克硝西泮10周的前、中、后三个阶段。服药期间睡眠更长且更完整，服用两个月后未出现明显耐受性。然而，停药后睡眠暂时比服药前更差。硝西泮会减少慢波睡眠，但伴随的生长激素分泌并未受损。
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