Alsafwah Shadwan, Ramanathan Kodangudi B
Division of Cardiovascular Diseases, University of Tennessee Health Science Center and Veterans Administration Medical Center, Memphis, Tennessee, USA.
Am J Med Sci. 2008 May;335(5):368-74. doi: 10.1097/MAJ.0b013e31815c3b32.
With the advent of effective antiatherosclerotic therapies, especially lipid lowering agents, cardiovascular morbidity and mortality rates associated with coronary atherosclerosis can be reduced. A growing body of evidence suggests such therapies can retard the progression of coronary atherosclerosis and with aggressive treatment regimens can cause regression. Antiatherosclerotic, and especially lipid lowering therapies, have the potential to become an alternative to invasive interventions. This report examines clinical studies that have addressed the regression of human coronary atherosclerosis by medical therapy.
随着有效抗动脉粥样硬化疗法的出现，尤其是降脂药物的问世，与冠状动脉粥样硬化相关的心血管发病率和死亡率得以降低。越来越多的证据表明，此类疗法能够延缓冠状动脉粥样硬化的进展，并且采用积极的治疗方案可使其发生逆转。抗动脉粥样硬化疗法，尤其是降脂疗法，有可能成为侵入性干预措施的替代方法。本报告审视了通过药物治疗使人类冠状动脉粥样硬化发生逆转的临床研究。
