Kieburtz K D, Giang D W, Schiffer R B, Vakil N
Department of Neurology, University of Rochester, School of Medicine, NY 14642.
Arch Neurol. 1991 Mar;48(3):312-4. doi: 10.1001/archneur.1991.00530150082023.
An increased prevalence of vitamin B12 deficiency has been reported in patients infected by the human immunodeficiency virus (HIV). We report an unexpectedly high prevalence (20%) of such abnormal vitamin B12 metabolism in a population of HIV-infected patients referred for neurological evaluation. This abnormality was associated with both peripheral neuropathy and myelopathy. A majority of those treated with cyanocobalamin had a therapeutic response. Selected neuropathological results suggest a relationship between vitamin B12 deficiency and vacuolar myelopathy. Vitamin B12 deficiency may be a frequent and treatable cause of neurological dysfunction in patients with HIV infection.
据报道，感染人类免疫缺陷病毒（HIV）的患者中维生素B12缺乏的患病率有所增加。我们报告了一组因神经功能评估前来就诊的HIV感染患者中，这种维生素B12代谢异常的患病率出乎意料地高（20%）。这种异常与周围神经病变和脊髓病均有关联。大多数接受钴胺素治疗的患者有治疗反应。部分神经病理学结果提示维生素B12缺乏与空泡性脊髓病之间存在关联。维生素B12缺乏可能是HIV感染患者神经功能障碍的常见且可治疗的原因。
