人类免疫缺陷病毒（HIV）感染中的维生素B12缺乏与神经系统疾病
Vitamin B12 deficiency and nervous system disease in HIV infection.
作者信息
Robertson K R, Stern R A, Hall C D, Perkins D O, Wilkins J W, Gortner D T, Donovan M K, Messenheimer J A, Whaley R, Evans D L
机构信息
AIDS Neurological Center, University of North Carolina, Chapel Hill 27599-7025.
出版信息
Arch Neurol. 1993 Aug;50(8):807-11. doi: 10.1001/archneur.1993.00540080018007.
BACKGROUND
Vitamin B12 deficiency may result in a number of neurological and neuropsychiatric disorders. Patients with human immunodeficiency virus type 1 (HIV-1) infection may have a high rate of vitamin B12 deficiency and nervous system disease. Vitamin B12 deficiency may contribute to neurological disease in HIV-1-infected individuals.
OBJECTIVE
To evaluate the possible contribution of vitamin B12 deficiency to neurological disease in HIV-1-infected individuals.
MAIN OUTCOME MEASURES
Comparison of serum vitamin B12 levels with neurological, neuropsychological, and mood state abnormalities in 153 HIV-1-positive subjects and 57 high-risk seronegative controls. A subgroup of 67 subjects underwent additional extensive clinical neurophysiological, cerebrospinal fluid, and magnetic resonance imaging evaluations.
RESULTS
No statistically significant relationships were noted between vitamin B12 levels and abnormalities on any of the measures examined.
CONCLUSIONS
This study does not indicate an important role for vitamin B12 deficiency in the neurological disease of HIV-1 infection.
背景
维生素B12缺乏可能导致多种神经和神经精神疾病。1型人类免疫缺陷病毒（HIV-1）感染患者可能有较高的维生素B12缺乏率和神经系统疾病发生率。维生素B12缺乏可能导致HIV-1感染个体出现神经疾病。
目的
评估维生素B12缺乏对HIV-1感染个体神经疾病的可能影响。
主要观察指标
比较153名HIV-1阳性受试者和57名高危血清阴性对照者的血清维生素B12水平与神经、神经心理和情绪状态异常情况。67名受试者的亚组接受了额外广泛的临床神经生理学、脑脊液和磁共振成像评估。
结果
在所检查的任何指标上，维生素B12水平与异常情况之间均未发现具有统计学意义的关系。
结论
本研究未表明维生素B12缺乏在HIV-1感染所致神经疾病中起重要作用。
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