Lucas Cheré R, Ke Malcolm S, Matsui Mary S, Maes Daniel, Cooper Kevin D, Stevens Seth R, Baron Elma D
Department of Dermatology, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, OH 44106, USA.
J Cosmet Dermatol. 2008 Jun;7(2):132-5. doi: 10.1111/j.1473-2165.2008.00376.x.
Ultraviolet (UV) light damages DNA and impairs immune surveillance. The faulty repair of DNA after UV exposure is associated with immune suppression and facilitates photodamage that leads to photoaged skin and the growth of skin cancer. Sunscreens have been developed to filter UV light from entering the skin, but are not beneficial once DNA damage has occurred. Enhancing DNA repair after UV radiation may provide added advantage and prevent UV immunosuppression. This study was performed to determine whether a product with DNA repair ingredients prevents UV-induced suppression of contact hypersensitivity responses in vivo. Solar simulated radiation was delivered on skin with and without topical treatment with a moisturizer containing DNA repair enzymes (Advanced Night Repair Concentrate). Subjects were then sensitized to the hapten dinitrochlorobenzene, and the level of resultant contact hypersensitivity response was elicited 2 weeks later. Contact hypersensitivity response measured by skin fold thickness was significantly suppressed in untreated UV-irradiated subjects but not in subjects treated with DNA repair moisturizer after solar simulated radiation. Our results indicate that DNA repair ingredients significantly prevent UV-induced immune suppression.
紫外线（UV）会损伤DNA并损害免疫监视功能。紫外线照射后DNA的错误修复与免疫抑制相关，并会促进光损伤，进而导致皮肤光老化和皮肤癌的发生。人们研发了防晒霜来过滤紫外线，防止其进入皮肤，但一旦DNA损伤已经发生，防晒霜就不再有益。增强紫外线辐射后的DNA修复可能会带来额外的益处，并预防紫外线免疫抑制。本研究旨在确定一种含有DNA修复成分的产品是否能在体内预防紫外线诱导的接触性超敏反应抑制。在有或没有局部涂抹含有DNA修复酶的保湿剂（特润修护精华露）的情况下，对皮肤进行太阳模拟辐射。然后让受试者对二硝基氯苯半抗原致敏，两周后引发由此产生的接触性超敏反应水平。通过皮肤褶皱厚度测量的接触性超敏反应在未经处理的紫外线照射受试者中受到显著抑制，但在接受太阳模拟辐射后使用DNA修复保湿剂处理的受试者中则未受抑制。我们的结果表明，DNA修复成分能显著预防紫外线诱导的免疫抑制。
