Hanneman Kaija K, Scull Heather M, Cooper Kevin D, Baron Elma D
Department of Dermatology, Skin Study Center, University Hospitals of Cleveland/Case Western Reserve University, Cleveland, Ohio 44106, USA.
Arch Dermatol. 2006 Oct;142(10):1332-4. doi: 10.1001/archderm.142.10.1332.
The immunomodulatory role of vitamin D and its analogues has been demonstrated in vitro and in vivo using animal models. We evaluated the effect of a vitamin D analogue, calcipotriene, in vivo on human subjects using a contact hypersensitivity model.
Subjects were pretreated with topical calcipotriene, simulated solar radiation, or both on buttock skin. They were then sensitized and challenged using the contact allergen dinitrochlorobenzene. Immune response was measured by change in skinfold thickness before vs after elicitation across the challenge sites.
Calcipotriene-treated individuals demonstrated 64% immunosuppression compared with untreated controls. This is equivalent to the immunosuppression induced by UV exposure.
维生素D及其类似物的免疫调节作用已在体外和使用动物模型的体内实验中得到证实。我们使用接触性超敏反应模型评估了一种维生素D类似物卡泊三烯在人体中的体内作用。
受试者在臀部皮肤局部使用卡泊三烯、模拟太阳辐射或两者同时进行预处理。然后使用接触性变应原二硝基氯苯对他们进行致敏和激发。通过激发前后激发部位皮褶厚度的变化来测量免疫反应。
与未治疗的对照组相比，接受卡泊三烯治疗的个体表现出64%的免疫抑制。这等同于紫外线照射所诱导的免疫抑制。
