Intervet UK Ltd, Houghton, Huntingdon, UK.
Avian Pathol. 1998;27(3):313-5. doi: 10.1080/03079459808419343.
Four serotype 1 Marek's disease virus (MDV) strains were isolated from Marek's disease (MD) outbreaks in Germany and Spain and their virulence was tested in SPF White Leghorn chickens. Two of the isolates from Germany (MR48/1-2 and /2-8) induced early mortality from cytolytic MD in 25% of the chickens whereas one isolate from Germany (MR48/3-16) caused early mortality in 58% of the inoculated chickens. Histological examination showed severe depletion of the lymphoid tissue of the bursa of Fabricius and the thymus, consistent with the cytolytic phase of MD. AH surviving chickens later developed acute MD in the form of multiple visceral tumours. Inoculation of SPF chickens with various doses of the isolate MR36 8/1C (Spain) caused early mortality in up to 69% of the chickens and acute MD in 92 to 100% of the chickens surviving the cytolytic phase of the disease.
从德国和西班牙的马立克氏病（MD）暴发中分离到了 4 株血清 1 型马立克氏病病毒（MDV）株，并在 SPF 白来航鸡中测试了它们的毒力。来自德国的 2 个分离株（MR48/1-2 和 /2-8）导致 25%的鸡发生溶细胞性 MD 早期死亡，而来自德国的 1 个分离株（MR48/3-16）导致接种鸡的 58%早期死亡。组织学检查显示法氏囊和胸腺的淋巴组织严重耗竭，与 MD 的溶细胞期一致。幸存的所有鸡后来都以多发性内脏肿瘤的形式发生急性 MD。用不同剂量的分离株 MR36 8/1C（西班牙）接种 SPF 鸡，导致高达 69%的鸡早期死亡，而在溶细胞期幸存下来的鸡中，92%至 100%发生急性 MD。
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