Bennett R M, Clark S R, Campbell S M, Ingram S B, Burckhardt C S, Nelson D L, Porter J M
Division of Arthritis and Rheumatic Diseases, Oregon Health Sciences University, Portland 97201.
Arthritis Rheum. 1991 Mar;34(3):264-9. doi: 10.1002/art.1780340303.
Twenty-nine female patients with fibromyalgia were questioned about symptoms of cold intolerance and Raynaud's syndrome; objective documentation of cold-induced vasospasm was obtained by a Nielsen test. Twelve patients (41%) had abnormal Nielsen test results, and 11 patients (38%) had elevated levels of platelet alpha 2-adrenergic receptors. There was a positive correlation between the percentage of change in finger systolic pressure on cooling (Nielsen test) and the number of alpha 2-adrenergic receptors. There was poor correlation between Raynaud's syndrome symptoms and an abnormal Nielsen test result. Digital photoplethysmography showed a normal waveform in 2 of 3 patients. We hypothesize that a subgroup of patients with fibromyalgia syndrome have an up-regulation of alpha 2-adrenergic receptors as a cause of their exaggerated reaction to cold.
对29名纤维肌痛女性患者询问了不耐寒症状和雷诺综合征症状；通过尼尔森试验客观记录了冷诱导血管痉挛情况。12名患者（41%）尼尔森试验结果异常，11名患者（38%）血小板α2 - 肾上腺素能受体水平升高。降温时手指收缩压变化百分比（尼尔森试验）与α2 - 肾上腺素能受体数量之间存在正相关。雷诺综合征症状与尼尔森试验异常结果之间相关性较差。3名患者中有2名经数字光电容积描记法显示波形正常。我们推测，纤维肌痛综合征患者的一个亚组存在α2 - 肾上腺素能受体上调，这是其对寒冷反应过度的原因。
