Vento A R, LaBrie R A, Mulliken J B
Harvard Medical School, Boston, MA.
Cleft Palate Craniofac J. 1991 Jan;28(1):68-76; discussion 77. doi: 10.1597/1545-1569_1991_028_0068_tomens_2.3.co_2.
The wide spectrum of anomalies associated with hemifacial microsomia (HFM) has made systematic and inclusive classification difficult. We propose a nosologic system in which each letter of the acronym O.M.E.N.S. indicates one of the five major manifestations of HFM. O for orbital distortion; M for mandibular hypoplasia; E for ear anomaly; N for nerve involvement; and S for soft tissue deficiency. The O.M.E.N.S. system is easily adapted for data storage, retrieval, and statistical analysis. A retrospective study of 154 patients with HFM classified according to the O.M.E.N.S. system confirmed the concept that the mandibular deformity is the cornerstone of the anomaly. Statistical analysis demonstrated a positive association between mandibular hypoplasia and the severity of orbital, auricular, neural, and soft tissue involvement. This study did not confirm a previously reported predominance of gender or sidedness. Analysis of statistical correlations failed to substantiate a Goldenhar variant as a syndromic entity. Our analysis showed that palatal deviation is probably caused by muscular hypoplasia and not by weakness of a particular cranial nerve.
与半侧颜面短小畸形（HFM）相关的异常表现范围广泛，这使得进行系统且全面的分类变得困难。我们提出了一种疾病分类系统，其中首字母缩略词O.M.E.N.S.的每个字母代表HFM的五种主要表现之一。O代表眼眶畸形；M代表下颌骨发育不全；E代表耳部异常；N代表神经受累；S代表软组织缺损。O.M.E.N.S.系统很容易适用于数据存储、检索和统计分析。一项对154例根据O.M.E.N.S.系统分类的HFM患者的回顾性研究证实了下颌骨畸形是该异常的基石这一概念。统计分析表明下颌骨发育不全与眼眶、耳部、神经和软组织受累的严重程度之间存在正相关。本研究未证实先前报道的性别或患侧优势。对统计相关性的分析未能证实戈尔登哈综合征变体是一种综合征实体。我们的分析表明，腭部偏斜可能是由肌肉发育不全引起的，而不是由特定颅神经的功能减弱所致。
