Mellink W A, Holland R, Hendriks J H, Peeters P H, Rutgers E J, van Daal W A
Department of Radiotherapy, University Hospital Nijmegen, The Netherlands.
Cancer. 1991 Apr 1;67(7):1844-8. doi: 10.1002/1097-0142(19910401)67:7<1844::aid-cncr2820670705>3.0.co;2-w.
The role of routine mammography was assessed in the early detection of asynchronous contralateral breast cancer (ACBC). The breast cancer patient populations of two cities, Nijmegen and Eindhoven, The Netherlands, which were subjected to a well-defined follow-up program, were compared. The program consisted of regular physical examination and annual mammography in Nijmegen and physical examination only in Eindhoven. From 1975 until 1987, 24 ACBC patients were detected within a group of 880 breast cancer patients in Nijmegen (3%) and, from 1971 until 1984, 14 ACBC patients within a group of 411 patients in Eindhoven (3%). In Nijmegen, eight of the 23 evaluable patients (35%) had a contralateral tumor with a histologic size smaller than 10 mm or an in situ carcinoma, compared with one of the 14 of the Eindhoven patients (7%), whereas 18 of the 24 (75%) versus eight of the 14 patients (57%) were node-negative. Thus annual mammography is very likely a contribution in the early detection of contralateral breast cancer as compared with follow-up by regular physical examination only.
评估了常规乳腺钼靶摄影在异时性对侧乳腺癌（ACBC）早期检测中的作用。比较了荷兰奈梅亨和埃因霍温两个城市的乳腺癌患者群体，这两个群体都接受了明确的随访计划。该计划在奈梅亨包括定期体格检查和年度乳腺钼靶摄影，而在埃因霍温仅包括体格检查。1975年至1987年期间，在奈梅亨的880例乳腺癌患者群体中检测到24例ACBC患者（3%），1971年至1984年期间，在埃因霍温的411例患者群体中检测到14例ACBC患者（3%）。在奈梅亨，23例可评估患者中有8例（35%）对侧肿瘤的组织学大小小于10毫米或为原位癌，而在埃因霍温的14例患者中有1例（7%）；奈梅亨24例患者中有18例（75%）腋窝淋巴结阴性，埃因霍温14例患者中有8例（57%）腋窝淋巴结阴性。因此，与仅通过定期体格检查进行随访相比，年度乳腺钼靶摄影很可能有助于对侧乳腺癌的早期检测。
