Chen Yan, Wei Xiaoyi, Xie Haihui, Deng Hongzhu
Department of Pharmacology, School of Traditional Chinese Medicine, Southern Medical UniVersity, Guangzhou 510515, People's Republic of China.
J Nat Prod. 2008 Jun;71(6):929-32. doi: 10.1021/np800016e. Epub 2008 May 17.
Two 2-phenylbenzofurans, lespedezavirgatol (1) and lespedezavirgatal (2), and a coumestan, lespedezacoumestan (3), were isolated from the aerial parts of Lespedeza virgata, together with nine known flavonoids. Their structures were determined on the basis of spectroscopic data. The three new compounds showed strong oxygen radical absorbance capacity and potent inhibition toward lipid peroxidation in both plasma and kidney homogenate of renal failure rats.
从长穗胡枝子的地上部分分离得到两种2-苯基苯并呋喃，即长穗胡枝子醇（1）和长穗胡枝子醛（2），以及一种香豆雌酚，即长穗胡枝子香豆雌酚（3），同时还分离得到9种已知的黄酮类化合物。它们的结构通过光谱数据确定。这三种新化合物在肾衰竭大鼠的血浆和肾匀浆中均表现出较强的氧自由基吸收能力和对脂质过氧化的有效抑制作用。
