小花蒿地上部分的化学成分。

Chemical constituents from the aerial parts of Artemisia minor.

作者信息

He Zhi-Zhou, Yan Ju-Fang, Song Zhi-Jun, Ye Fei, Liao Xun, Peng Shu-Lin, Ding Li-Sheng

机构信息

National Engineering Research Center for Natural Medicines, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People's Republic of China.

出版信息

J Nat Prod. 2009 Jun;72(6):1198-201. doi: 10.1021/np800643n.

DOI:10.1021/np800643n

PMID:19476336

Abstract

Four new compounds including three bicoumarins, arteminorins A-C (1-3), and one neolignan, arteminorin D (4), together with 31 known ones were isolated from the aerial parts of Artemisia minor. Their structures were established on the basis of spectroscopic data and comparison with those of the related known compounds. Ethyl caffeate (27) showed in vitro cytotoxicity against the HepG2 cancer cell line. Arteminorin C (3) and luteolin (19) showed inhibitory activity on xanthine oxidase (XOD), and caffeic acid (28) exhibited inhibitory activity on protein tyrosine phosphatase 1B (PTP1B).

摘要

从小花蒿地上部分分离得到4个新化合物，包括3个双香豆素类化合物，即青蒿次素A - C（1 - 3）和1个新木脂素类化合物，青蒿次素D（4），以及31个已知化合物。它们的结构通过光谱数据并与相关已知化合物进行比较得以确定。咖啡酸乙酯（27）对肝癌细胞系HepG2显示出体外细胞毒性。青蒿次素C（3）和木犀草素（19）对黄嘌呤氧化酶（XOD）表现出抑制活性，咖啡酸（28）对蛋白酪氨酸磷酸酶1B（PTP1B）表现出抑制活性。