Barry R B M, Hughes B R, Cook L J
Portsmouth Dermatology Centre, St Mary's Hospital, Portsmouth, Hampshire, UK.
Clin Exp Dermatol. 2008 Jul;33(4):446-9. doi: 10.1111/j.1365-2230.2007.02676.x. Epub 2008 May 15.
Infantile haemangioma is a common childhood condition, which usually resolves spontaneously and is managed expectantly. In a small percentage of complex cases, haemangiomas may be associated with complications such as persistent bleeding, ulceration, feeding difficulties or visual impairment. Active treatment is often necessary in such cases. Current interventions include surgical, laser and immunomodulatory treatments. Imiquimod 5% cream is a novel alternative topical treatment that may have a potential role in management of these patients. We present our experience of imiquimod 5% cream in the treatment of five children with difficult haemangiomas. We discuss its efficacy and some of the side effects that may be encountered, which have not previously been reported.
婴儿血管瘤是一种常见的儿童疾病，通常会自行消退，一般采取观察等待的处理方式。在一小部分复杂病例中，血管瘤可能会伴有持续出血、溃疡、喂养困难或视力损害等并发症。在这种情况下，往往需要积极治疗。目前的干预措施包括手术、激光和免疫调节治疗。5%咪喹莫特乳膏是一种新型的局部替代治疗方法，可能在这些患者的治疗中发挥潜在作用。我们介绍了使用5%咪喹莫特乳膏治疗5例难治性血管瘤患儿的经验。我们讨论了其疗效以及可能遇到的一些副作用，这些副作用此前尚未见报道。
