Peng H Q, Liu S L, Mann V, Rohan T, Rawls W
Department of Obstetrics and Gynecology, West China University of Medical Sciences, Chengdu, Sichuan.
Int J Cancer. 1991 Mar 12;47(5):711-6. doi: 10.1002/ijc.2910470515.
Cancer of the cervix is relatively common in China, but has been investigated epidemiologically in only a few studies. In the hospital-based case-control study reported here, we investigated the role of various lifestyle and dietary factors, as well as infection with human papillomavirus (HPV) types 16 and 33 and herpes simplex virus type 2 in the aetiology of invasive cervical cancer. The study was conducted in Sichuan province, and involved 101 cases with histologically-confirmed cervical cancer recruited from the gynaecological oncology clinic of the West China University Hospital, and 146 controls recruited from patients attending the gynaecology clinic of the same hospital. Risk of cervical cancer was greatly increased in association with infection with HPV 16/33, the adjusted odds ratio for those with evidence of infection being 32.9 (95% CI 7.7-141.1). In contrast, infection with HSV 2 was not associated with a significantly altered risk of cervical cancer. Indices of sexual history and of dietary habits also showed no association with risk of cervical cancer, while good personal and genital hygiene were associated with markedly reduced risk. Although the results of this study are consistent with a causal role for HPV in the aetiology of cervical cancer, bias or increased viral expression following malignant transformation cannot be excluded as explanations for the strong positive association.
宫颈癌在中国相对常见，但仅有少数研究对其进行过流行病学调查。在本文报告的一项基于医院的病例对照研究中，我们调查了各种生活方式和饮食因素，以及16型和33型人乳头瘤病毒（HPV）感染和2型单纯疱疹病毒感染在浸润性宫颈癌病因学中的作用。该研究在四川省开展，纳入了101例经组织学确诊的宫颈癌病例，这些病例来自华西医院妇科肿瘤门诊，同时纳入了146名对照，这些对照来自同一医院妇科门诊的患者。与HPV 16/33感染相关的宫颈癌风险大幅增加，有感染证据者的校正比值比为32.9（95%可信区间7.7 - 141.1）。相比之下，2型单纯疱疹病毒感染与宫颈癌风险的显著改变无关。性史和饮食习惯指标也与宫颈癌风险无关，而良好的个人卫生和生殖器官卫生与风险显著降低相关。尽管本研究结果与HPV在宫颈癌病因学中的因果作用一致，但不能排除偏倚或恶性转化后病毒表达增加作为强阳性关联的解释。
