Berraho Mohamed, Amarti-Riffi Afaf, El-Mzibri Mohammed, Bezad Rachid, Benjaafar Noureddine, Benideer Abdelatif, Matar Noureddine, Qmichou Zinab, Abda Naima, Attaleb Mohammed, Znati Kaoutar, El Fatemi Hind, Bendahhou Karima, Obtel Majdouline, Filali Adib Abdelhai, Mathoulin-Pelissier Simone, Nejjari Chakib
Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine and Pharmacy, University Sidi Mohammed Benabdellah, BP.1893, Km 2.2 Route Sidi Harazem, Fez, Morocco.
Pathological Anatomy Laboratory, CHU Hassan-II, Fez, Morocco.
BMC Cancer. 2017 Jun 20;17(1):435. doi: 10.1186/s12885-017-3425-z.
Limited national information is available in Morocco on the prevalence and distribution of HPV-sub-types of cervical cancer and the role of other risk factors. The aim was to determine the frequency of HPV-sub-types of cervical cancer in Morocco and investigate risk factors for this disease.
Between November 2009 and April 2012 a multicentre case-control study was carried out. A total of 144 cases of cervical cancer and 288 age-matched controls were included. Odds-ratios and corresponding confidence-intervals were computed by conditional logistic regression models.
Current HPV infection was detected in 92.5% of cases and 13.9% of controls. HPV16 was the most common type for both cases and controls. Very strong associations between HPV-sub-types and cervical cancer were observed: total-HPV (OR = 39), HPV16 (OR = 49), HPV18 (OR = 31), and multiple infections (OR = 13). Education, high parity, sexual intercourse during menstruation, history of sexually transmitted infections, and husband's multiple sexual partners were also significantly associated with cervical cancer in the multivariate analysis.
Our results could be used to establish a primary prevention program and to prioritize limited screening to women who have specific characteristics that may put them at an increased risk of cervical cancer.
在摩洛哥，关于宫颈癌人乳头瘤病毒（HPV）亚型的患病率、分布情况以及其他风险因素的作用，国内可获取的信息有限。本研究旨在确定摩洛哥宫颈癌HPV亚型的感染频率，并调查该疾病的风险因素。
2009年11月至2012年4月期间开展了一项多中心病例对照研究。共纳入144例宫颈癌病例和288例年龄匹配的对照。通过条件逻辑回归模型计算比值比及相应的置信区间。
92.5%的病例和13.9%的对照检测到当前HPV感染。HPV16是病例组和对照组中最常见的类型。观察到HPV亚型与宫颈癌之间存在非常强的关联：总HPV（比值比=39）、HPV16（比值比=49）、HPV18（比值比=31）以及多重感染（比值比=13）。在多变量分析中，教育程度、多产、经期性交、性传播感染史以及丈夫的多个性伴侣也与宫颈癌显著相关。
我们的研究结果可用于制定一级预防计划，并将有限的筛查重点放在具有可能使其患宫颈癌风险增加的特定特征的女性身上。
