Wakefield C E, Meiser B, Gaff C L, Barratt A, Patel M I, Suthers G, Lobb E A, Ramsay J, Mann G J
Psychosocial Research Group, Department of Medical Oncology, Prince of Wales Hospital, Randwick, Australia.
J Urol. 2008 Jul;180(1):38-46; discussion 46. doi: 10.1016/j.juro.2008.03.020. Epub 2008 May 15.
Despite the established importance of the role of family history in prostate cancer, relatively little research encompasses the psychosocial issues relevant to unaffected men with a family history of prostate cancer. To determine the completeness and quality of available literature on the issues faced by men with a high risk of prostate cancer, we conducted a multidisciplinary review of the literature to provide some guidance on the information that clinicians might provide to men who are concerned about family history.
A structured literature search was conducted by a multidisciplinary team of clinicians and researchers who reviewed the medical and psychosocial literature, and identified 21 relevant studies.
Research suggests that many high risk patients are concerned about the risk of prostate cancer, and some may significantly overestimate that risk. Several studies have shown high screening rates among high risk patients and high levels of interest in genetic testing for prostate cancer risk should it become available, yet many men also report a desire for more information about their personal risk and risk management options.
Given the lack of clear data on the efficacy of prostate cancer screening among high risk patients, clinicians could consider providing men who are concerned about family history with information on their personal risk, help them to clarify the potential benefits, limitations and harms of prostate cancer screening in their situation, and then support their choice regarding the management of prostate cancer risk.
尽管家族史在前列腺癌中的作用已得到公认，但相对较少的研究涉及与有前列腺癌家族史的未患病男性相关的社会心理问题。为了确定关于前列腺癌高危男性所面临问题的现有文献的完整性和质量，我们对文献进行了多学科综述，以便为临床医生可能向担心家族史的男性提供的信息提供一些指导。
由临床医生和研究人员组成的多学科团队进行了结构化文献检索，他们查阅了医学和社会心理文献，并确定了21项相关研究。
研究表明，许多高危患者担心患前列腺癌的风险，有些人可能会显著高估这种风险。几项研究显示高危患者的筛查率很高，并且如果有针对前列腺癌风险的基因检测，他们对其兴趣浓厚，但许多男性也表示希望获得更多关于个人风险和风险管理选择的信息。
鉴于缺乏关于高危患者前列腺癌筛查疗效的明确数据，临床医生可以考虑向担心家族史的男性提供有关其个人风险的信息，帮助他们阐明在其情况下前列腺癌筛查的潜在益处、局限性和危害，然后支持他们对前列腺癌风险管理的选择。
