Hinson J P, Vinson G P, Kapas S, Teja R
Department of Biochemistry, Medical College of St Bartholomew's Hospital, Charterhouse Square, London.
J Endocrinol. 1991 Feb;128(2):275-80. doi: 10.1677/joe.0.1280275.
The rate of blood flow through the intact adrenal gland is closely linked to steroid hormone secretion, and although the mechanism involved is unknown, it is thought to involve secretory products of the vascular endothelium. In dispersed cell preparations, endothelin-1 and -3 both caused a dose-dependent and highly sensitive increase in steroid secretion by zona glomerulosa and zona fasciculata cells of the rat and human adrenal cortex. In addition, when the perfused rat adrenal was stimulated with ACTH, significant increases in steroid secretion and perfusion medium flow rate were accompanied by significantly increased secretion of immunoreactive endothelin into the adrenal vein. It is proposed that endothelin has a role in mediating the adrenocortical response to ACTH stimulation.
流经完整肾上腺的血流速率与甾体激素分泌密切相关，尽管其中涉及的机制尚不清楚，但据认为这与血管内皮的分泌产物有关。在分散细胞制剂中，内皮素-1和-3均可使大鼠和人类肾上腺皮质球状带和束状带细胞的甾体分泌呈剂量依赖性且高度敏感地增加。此外，当用促肾上腺皮质激素刺激灌注的大鼠肾上腺时，甾体分泌和灌注介质流速的显著增加伴随着肾上腺静脉中免疫反应性内皮素分泌的显著增加。有人提出，内皮素在介导肾上腺皮质对促肾上腺皮质激素刺激的反应中起作用。
