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1
Bosentan may induce arthritis flare in patients with scleroderma concomitantly treated with methotrexate.波生坦可能会使正在接受甲氨蝶呤治疗的硬皮病患者出现关节炎发作。
Ann Rheum Dis. 2006 May;65(5):692-3. doi: 10.1136/ard.2005.044388.
2
Severe hepatotoxicity in a patient on bosentan upon addition of methotrexate: reversible with resumption of methotrexate without bosentan.波生坦治疗的患者加用甲氨蝶呤后出现严重肝毒性:停用波生坦后恢复甲氨蝶呤治疗,肝毒性可逆转。
J Clin Rheumatol. 2009 Mar;15(2):88-9. doi: 10.1097/RHU.0b013e31819bc71f.
3
Liver impairment after concomitant administration of bosentan and clarithromycin in systemic sclerosis.系统性硬化症患者同时服用波生坦和克拉霉素后出现肝功能损害。
Joint Bone Spine. 2010 Jan;77(1):81-2. doi: 10.1016/j.jbspin.2009.04.010. Epub 2009 Dec 22.
4
Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension.在肺动脉高压患者中,西地那非联合波生坦单药治疗。
Eur Respir J. 2007 Mar;29(3):469-75. doi: 10.1183/09031936.00081706. Epub 2006 Nov 1.
5
Drug eruption due to bosentan in a patient with systemic sclerosis.一名系统性硬化症患者因波生坦引起的药疹。
Mod Rheumatol. 2006;16(3):188-90. doi: 10.1007/s10165-006-0477-3.
6
Bosentan: a review of its use in pulmonary arterial hypertension and systemic sclerosis.波生坦:其在肺动脉高压和系统性硬化症中的应用综述
Am J Cardiovasc Drugs. 2006;6(3):189-208. doi: 10.2165/00129784-200606040-00001.
7
Delayed hypersensitivity to bosentan.对波生坦的迟发型超敏反应。
Allergy. 2009 Mar;64(3):499-501. doi: 10.1111/j.1398-9995.2008.01927.x. Epub 2009 Feb 12.
8
Endothelin receptor antagonist bosentan improves the dermal sclerosis in a patient with systemic sclerosis.内皮素受体拮抗剂波生坦改善系统性硬皮病患者的皮肤硬化。
Australas J Dermatol. 2012 May;53(2):e32-3. doi: 10.1111/j.1440-0960.2010.00719.x. Epub 2010 Nov 29.
9
Effects of bosentan on the skin lesions: an observational study from a single center in Japan.波生坦对皮肤病变的影响:来自日本单中心的一项观察性研究。
Rheumatol Int. 2009 May;29(7):769-75. doi: 10.1007/s00296-008-0789-z. Epub 2008 Nov 27.
10
Bosentan improves functional class, pulmonary artery systolic pressure, and DLCO in scleroderma patients with pulmonary hypertension: a possible synergy with iloprost.
J Rheumatol. 2006 Sep;33(9):1915-6; author reply 1916.

本文引用的文献

1
Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study.双重内皮素受体拮抗剂波生坦治疗肺动脉高压患者的疗效:一项1年随访研究
Chest. 2003 Jul;124(1):247-54. doi: 10.1378/chest.124.1.247.
2
Bosentan therapy for pulmonary arterial hypertension.波生坦治疗肺动脉高压
N Engl J Med. 2002 Mar 21;346(12):896-903. doi: 10.1056/NEJMoa012212.
3
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study.双重内皮素受体拮抗剂波生坦治疗肺动脉高压患者的疗效:一项随机安慰剂对照研究。
Lancet. 2001 Oct 6;358(9288):1119-23. doi: 10.1016/S0140-6736(01)06250-X.
4
Pharmacokinetics of low-dose methotrexate in rheumatoid arthritis patients.类风湿关节炎患者中低剂量甲氨蝶呤的药代动力学
J Pharm Sci. 1989 Feb;78(2):165-71. doi: 10.1002/jps.2600780219.
5
Suppression of rheumatoid factor production by methotrexate in patients with rheumatoid arthritis. Evidence for differential influences of therapy and clinical status on IgM and IgA rheumatoid factor expression.甲氨蝶呤对类风湿关节炎患者类风湿因子产生的抑制作用。治疗及临床状态对IgM和IgA类风湿因子表达的不同影响的证据。
Arthritis Rheum. 1990 Aug;33(8):1156-61. doi: 10.1002/art.1780330816.
6
The role of endothelin in the control of adrenocortical function: stimulation of endothelin release by ACTH and the effects of endothelin-1 and endothelin-3 on steroidogenesis in rat and human adrenocortical cells.内皮素在肾上腺皮质功能调控中的作用:促肾上腺皮质激素对内皮素释放的刺激以及内皮素-1和内皮素-3对大鼠和人肾上腺皮质细胞类固醇生成的影响。
J Endocrinol. 1991 Feb;128(2):275-80. doi: 10.1677/joe.0.1280275.

Bosentan may induce arthritis flare in patients with scleroderma concomitantly treated with methotrexate.

作者信息

Cozzi F, Ostuni P A, Marotta H, Sfriso P, Favaro M, Todesco S

出版信息

Ann Rheum Dis. 2006 May;65(5):692-3. doi: 10.1136/ard.2005.044388.

DOI:10.1136/ard.2005.044388
PMID:16611872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1798114/
Abstract
摘要