Holden Joseph A, Willmore-Payne Carlynn, Layfield Lester J
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
Exp Mol Pathol. 2008 Aug;85(1):68-75. doi: 10.1016/j.yexmp.2008.03.010. Epub 2008 Apr 10.
Constitutively activated tyrosine kinases play an important role in human malignancies. Their constant downstream signaling leads to cell proliferation and the inhibition of anti-apoptotic mechanisms. New cancer therapeutics have been designed to specifically target the activated kinases in human cancers and in some instances treatment with these agents leads to tumor regression. With the use of new molecular techniques, it is now possible in routine diagnostic work to characterize human malignancies with respect to the presence or absence of activated tyrosine kinases. This may have important predictive and prognostic implications.
组成性激活的酪氨酸激酶在人类恶性肿瘤中起重要作用。它们持续的下游信号传导导致细胞增殖并抑制抗凋亡机制。新的癌症治疗方法已被设计用于特异性靶向人类癌症中激活的激酶，在某些情况下，使用这些药物进行治疗会导致肿瘤消退。随着新分子技术的应用，现在在常规诊断工作中就激活酪氨酸激酶的存在与否来表征人类恶性肿瘤成为可能。这可能具有重要的预测和预后意义。
