表皮生长因子受体表达可预测猫皮肤鳞状细胞癌的不良预后。
Epidermal growth factor receptor expression is predictive of poor prognosis in feline cutaneous squamous cell carcinoma.
作者信息
Sabattini Silvia, Marconato Laura, Zoff Aurora, Morini Maria, Scarpa Filippo, Capitani Ombretta, Bettini Giuliano
机构信息
Department of Veterinary Public Health and Animal Pathology, Alma Mater Studiorum, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell'Emilia, Bologna, Italy.
出版信息
J Feline Med Surg. 2010 Oct;12(10):760-8. doi: 10.1016/j.jfms.2010.04.010. Epub 2010 Jul 31.
The aim of this study was to investigate epidermal growth factor receptor (EGFR) expression in feline cutaneous squamous cell carcinoma (FC-SCC) and assess its prognostic role. Nineteen formalin-fixed paraffin-embedded excisional biopsies of FC-SCC were tested for EGFR expression using immunohistochemistry (IHC). Relationships between EGFR expression and histopathological parameters (differentiation, mitotic activity), disease-free interval (DFI) and overall survival (OS) at 24 months were further investigated. Fourteen of 19 tumours (73.7%) were positive for EGFR, with great variation in intensity and proportion of labelled cells. EGFR expression was not correlated with tumour differentiation or mitotic activity. Nine cats (47.4%) died of tumour-related causes. Patients with EGFR-positive tumours had a significantly worse outcome (P=0.0217), with decreased DFIs (P=0.0075) and survival times (P=0.0391). These data suggest that EGFR expression carries a negative prognostic significance in FC-SCC. EGFR inhibitors in association with conventional treatments may improve outcome for the subgroup of cats with EGFR-positive tumours.
本研究旨在调查猫皮肤鳞状细胞癌（FC-SCC）中表皮生长因子受体（EGFR）的表达情况，并评估其预后作用。使用免疫组织化学（IHC）对19例FC-SCC的福尔马林固定石蜡包埋切除活检组织进行EGFR表达检测。进一步研究EGFR表达与组织病理学参数（分化程度、有丝分裂活性）、无病间期（DFI）以及24个月总生存期（OS）之间的关系。19个肿瘤中有14个（73.7%）EGFR呈阳性，标记细胞的强度和比例差异很大。EGFR表达与肿瘤分化程度或有丝分裂活性无关。9只猫（47.4%）死于肿瘤相关原因。EGFR阳性肿瘤患者的预后明显较差（P=0.0217），DFI降低（P=0.0075），生存时间缩短（P=0.0391）。这些数据表明，EGFR表达在FC-SCC中具有负面预后意义。EGFR抑制剂与传统治疗联合使用可能会改善EGFR阳性肿瘤猫亚组的预后。
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