Int J Cardiol. 2009 May 29;134(3):e117-9. doi: 10.1016/j.ijcard.2008.01.025. Epub 2008 May 19.
Hereby we report our observations derived from a study of 113 subjects who underwent coronary angiography; of whom 32 were free of coronary lesions (controls) and 27 underwent percutaneous coronary intervention (PCI). In this work, we aimed to investigate the dynamics of oxidized low-density lipoprotein (OxLDL) and the possible effect of PCI on its levels within the coronary circulation of patients with coronary artery disease. We concluded that the mechanical maneuvers applied during PCI may not result in immediate local elevation of OxLDL levels within the coronary circulation of patients with coronary artery disease. Besides, we hypothesized that coronary atheroma might fix OxLDL, especially if mechanically disrupted by PCI.
在此，我们报告了一项对 113 名接受冠状动脉造影检查的患者进行的研究观察结果；其中 32 例无冠状动脉病变（对照组），27 例行经皮冠状动脉介入治疗（PCI）。在这项工作中，我们旨在研究氧化型低密度脂蛋白（OxLDL）的动力学，以及 PCI 对冠心病患者冠状动脉循环中 OxLDL 水平的可能影响。我们得出结论，PCI 过程中应用的机械操作可能不会导致冠心病患者冠状动脉循环中 OxLDL 水平立即升高。此外，我们假设冠状动脉粥样硬化斑块可能会固定 OxLDL，特别是如果被 PCI 机械性破坏的话。
