用于向大脑进行药物和基因递送的超声技术。
Ultrasound for drug and gene delivery to the brain.
作者信息
Hynynen Kullervo
机构信息
Department of Medical Biophysics, University of Toronto, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada.
出版信息
Adv Drug Deliv Rev. 2008 Jun 30;60(10):1209-17. doi: 10.1016/j.addr.2008.03.010. Epub 2008 Apr 6.
Abstract
Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) has been demonstrated with focused ultrasound exposure in animal models. Most studies have combined low pressure amplitude and low time average acoustic power burst sonications with intravascular injection of pre-formed micro-bubbles to produce BBBD without damage to the neurons. The BBB has been shown to be healed within a few hours after the exposure. The combination of focused ultrasound beams with MR image guidance allows precise anatomical targeting as demonstrated by the delivery of several marker molecules in different animal models. This method may in the future have a significant impact on the diagnosis and treatment of central nervous system (CNS) disorders. Most notably, the delivery of the chemotherapy agents (liposomal Doxorubicin and Herceptin) has been shown in a rat model.
摘要
在动物模型中，通过聚焦超声照射已证明可实现无创、短暂和局部的图像引导血脑屏障破坏（BBBD）。大多数研究将低压力振幅和低时间平均声功率脉冲超声与血管内注射预先形成的微泡相结合，以产生BBBD而不损伤神经元。研究表明，暴露后血脑屏障在数小时内即可愈合。聚焦超声束与磁共振图像引导相结合，能够实现精确的解剖定位，这在不同动物模型中多种标记分子的递送中得到了证明。这种方法未来可能会对中枢神经系统（CNS）疾病的诊断和治疗产生重大影响。最值得注意的是，在大鼠模型中已证明了化疗药物（脂质体阿霉素和赫赛汀）的递送。
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Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index.聚焦超声和循环预形成微泡诱导的血脑屏障破坏似乎以机械指数为特征。
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