大分子通过血脑屏障的递送。
Macromolecular delivery across the blood-brain barrier.
作者信息
Hynynen Kullervo
机构信息
Department of Medical Biophysics, University of Toronto and Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON, Canada.
出版信息
Methods Mol Biol. 2009;480:175-85. doi: 10.1007/978-1-59745-429-2_13.
The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood-brain barrier (BBB). Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery.
通过血流将大分子递送至中枢神经系统（CNS）受到血脑屏障（BBB）的严重限制。使用聚焦超声照射并血管内注射预先形成的微泡，可以实现无创、短暂且局部的图像引导血脑屏障破坏（BBBD）。本章将详细描述动物中MRI引导的局灶性BBBD方法。该方法可能会开启中枢神经系统大分子药物递送的新时代。
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