Pathak Rahul, Suke Sanvidhan G, Ahmed Rafat S, Tripathi A K, Guleria Kiran, Sharma C S, Makhijani S D, Mishra Meenu, Banerjee B D
Department of Biochemistry, University College of Medical Sciences, Dilshad Garden, Delhi, 110 095, India.
Bull Environ Contam Toxicol. 2008 Aug;81(2):216-9. doi: 10.1007/s00128-008-9459-9. Epub 2008 May 17.
Humans are exposed to various environmental chemicals such as organochlorine pesticide residues, heavy metals, polychlorinatedbiphenyls (PCBs) etc. There is paucity of data regarding the present blood levels of organochlorine residues in North Indian population with reference to reproductive health. The present study was designed to analyze the levels of organochlorine pesticide residues in maternal and cord blood samples of normal healthy women with full term pregnancy to gain insight into the current status of pesticide burden in newborns. Hexachlorocyclohexane (HCH) contributed maximum towards the total organochlorine residues present in maternal and cord blood followed by endosulfan, pp' DDE and pp' DDT being the least. This is also the first report indicating endosulfan levels in this population. Our data indicates a transfer rate of 60-70% of these pesticides from mothers to newborns and this high rate of transfer of pesticides is of great concern as it may adversely affect the growth and development of newborn.
人类会接触到各种环境化学物质，如有机氯农药残留、重金属、多氯联苯（PCBs）等。关于北印度人群目前有机氯残留的血液水平与生殖健康的关系，相关数据匮乏。本研究旨在分析足月妊娠的正常健康女性母体和脐带血样本中有机氯农药残留水平，以深入了解新生儿农药负担的现状。六氯环己烷（HCH）在母体和脐带血中存在的总有机氯残留中占比最大，其次是硫丹，而p,p'-滴滴伊（pp' DDE）和p,p'-滴滴涕（pp' DDT）占比最小。这也是首次表明该人群中硫丹水平的报告。我们的数据表明，这些农药从母亲到新生儿的转移率为60%-70%，如此高的农药转移率令人高度担忧，因为它可能会对新生儿的生长发育产生不利影响。
