Environmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences & G.T.B. Hospital, University of Delhi, Dilshad Garden, Delhi, 110 095, India.
Environ Monit Assess. 2010 Dec;171(1-4):633-8. doi: 10.1007/s10661-010-1307-9. Epub 2010 Mar 2.
Aldrin and dieldrin, structurally similar organochlorine pesticides belong to cyclodiene family and were widely used for agriculture and public health program in India. Although the manufacturing, use and import of aldrin and dieldrin have been banned in India since 2003, these pesticides are still persistent in environment and may be associated with adverse neurological and reproductive effects. The aim of this study is to assess the recent exposure level of aldrin and dieldrin and their placental transfer to fetus in normal healthy full-term pregnant women belonging to north Indian population undergoing normal delivery at Obstetrics and Gynecology department of UCMS and GTB hospital, Delhi. Quantitative analysis of aldrin and dieldrin residues in maternal and cord blood samples were carried out by gas chromatography system equipped with electron capture detector. The results of our study clearly revealed that maternal and cord blood levels of aldrin and dieldrin of pregnant women are age and dietary habit dependent. The aldrin level in maternal blood and dieldrin level in cord blood are higher in women in the age group 25-30 years than in women in age group of 19-24 years. Similarly, aldrin level in maternal blood is significantly higher in women with non-vegetarian dietary habit than in women with vegetarian dietary habit. No significant association is found for maternal and cord blood level. The results of the present study clearly demonstrate prenatal uptake of aldrin and dieldrin and provide recent information on the subsequent transplacental transfer.
aldrin 和狄氏剂，结构相似的有机氯农药属于环二烯家族，曾被广泛用于农业和印度公共卫生项目。尽管 aldrin 和 dieldrin 的制造、使用和进口自 2003 年以来在印度被禁止，但这些农药仍然在环境中持续存在，可能与不良的神经和生殖影响有关。本研究旨在评估 aldrin 和 dieldrin 在北印度正常健康足月分娩的孕妇中的近期暴露水平及其向胎儿的胎盘转移情况。在 UCMS 和 GTB 医院的妇产科，通过配备电子捕获检测器的气相色谱系统对母体和脐带血样本中的 aldrin 和 dieldrin 残留进行定量分析。我们的研究结果清楚地表明，孕妇的母体和脐带血中的 aldrin 和 dieldrin 水平与年龄和饮食习惯有关。25-30 岁年龄组妇女的母体血液中的 aldrin 水平和脐带血中的 dieldrin 水平高于 19-24 岁年龄组妇女。同样，非素食饮食习惯的妇女的母体血液中的 aldrin 水平明显高于素食饮食习惯的妇女。母体和脐带血水平之间没有显著的相关性。本研究的结果清楚地表明了产前 aldrin 和 dieldrin 的摄取，并提供了随后胎盘转移的最新信息。
