Iakushevich L V, Krasnobaeva L A
Biofizika. 2008 Jan-Feb;53(1):36-41.
A mathematical model for studies of peculiar features of the dynamics of local conformational distortions (kinks) has been constructed. General formulas determining the dependence of the main dynamic characteristics of kinks: size, energy, density of energy, and velocity on the composition of inhomogeneous DNA have been obtained. Quantitative estimations of the characteristics have been made for kinks activated in inhomogeneous polynucleotide chains with sequences analogous to promoter sequences A1, A2, and A3 of bacteriophage T7 genome.
构建了一个用于研究局部构象畸变(纽结)动力学特性的数学模型。已获得确定纽结主要动力学特性(大小、能量、能量密度和速度)与非均匀DNA组成之间依赖关系的通用公式。对在具有类似于噬菌体T7基因组启动子序列A1、A2和A3的序列的非均匀多核苷酸链中激活的纽结的特性进行了定量估计。