Ohto H, Nomura H, Ohmura K, Ishijima A, Okazaki S
Blood Transfusion Service, Fukushima Medical College.
Rinsho Byori. 1991 Jan;39(1):14-7.
To evaluate the surrogate markers of non-A, non-B hepatitis virus (es) carriage state, the relationship between antibody to hepatitis C virus (HCV) and antibody to HBc/HBs and liver enzyme (ALT) was sought in Saitama prefecture. Out of 36,642 blood donor samples, 410 (1.1%) samples were positive for anti-HCV. Anti-HCV was found in 1.79% of donors with anti-HBs and/or anti-HBc, which is 1.7 fold of the frequency found in donors (1.04%) negative for anti-HBc/HBs. In contrast to the reports from Europe or USA, a poor correlation of anti-HCV with the serological history of hepatitis B infection was observed. These results indicate that hepatitis B and hepatitis C were transmitted independently in the Japanese, which is more homogeneous socioeconomically than the European or American populations. On the other hand, anti-HCV prevalence was in close correlation to ALT level as observed in the USA and in Europe. As we predicted previously, ALT can be expected to reduce the incidence of post-transfusion non-A, non-B hepatitis, however, anti-HBc can not.
为评估非甲非乙型肝炎病毒携带状态的替代标志物，在埼玉县研究了丙型肝炎病毒抗体（抗-HCV）与乙肝核心抗体/乙肝表面抗体及肝酶（ALT）之间的关系。在36642份献血者样本中，410份（1.1%）样本抗-HCV呈阳性。在有抗-HBs和/或抗-HBc的献血者中，1.79%发现有抗-HCV，这是抗-HBc/HBs阴性献血者（1.04%）中发现频率的1.7倍。与欧洲或美国的报告不同，观察到抗-HCV与乙肝感染血清学史的相关性较差。这些结果表明，在日本，乙肝和丙肝是独立传播的，日本社会经济比欧洲或美国人群更具同质性。另一方面，正如在美国和欧洲所观察到的，抗-HCV流行率与ALT水平密切相关。正如我们之前所预测的，ALT有望降低输血后非甲非乙型肝炎的发病率，然而，抗-HBc则不能。
