Bansal Ashish, Pradeep Keloth E, Gumparthy Krishna P
Department of Histopathology, Wirral Hospitals NHS Trust, Upton, Wirral, CH49 5PE, UK.
World J Surg Oncol. 2008 May 20;6:54. doi: 10.1186/1477-7819-6-54.
Low-grade papillary adenocarcinomas of the sinonasal tract are rare neoplasms. Over recent years, little doubt remains that this tumour represents a separate entity based on morphology, ultrastructural features and behaviour. We outline a case of this rare entity displaying a not hitherto described immunophenotype.
A 32 year old man presented recurrent epistaxis was evaluated with endoscopy which revealed a well circumscribed pedunculated mass lesion in left nares. The mass was arising from the nasal septum which was excised along with the mass. The biopsy revealed low-grade, non-intestinal type sinonasal tubulopapillary adenocarcinoma.
TTF-1 immunoreactivity in absence of thyroid or pulmonary primary in the present case remains an enigma. However, this raises the possibility of the utility of this antibody to predict a better clinical outcome in the subset of low grade non-intestinal sinonasal adenocarcinoma. More cases of similar morphological appearance may need to be examined for TTF-1 immunoreactivity and clinically followed up to establish this theory.
鼻窦低度乳头状腺癌是罕见的肿瘤。近年来，毫无疑问，基于形态学、超微结构特征和行为，这种肿瘤代表一个独立的实体。我们概述了一例表现出迄今未描述的免疫表型的这种罕见实体病例。
一名32岁男性因反复鼻出血接受内镜检查，发现左侧鼻孔有一个边界清楚的带蒂肿块病变。肿块起源于鼻中隔，连同肿块一起切除。活检显示为低度、非肠型鼻窦管状乳头状腺癌。
在本病例中，甲状腺或肺部无原发灶时TTF-1免疫反应性仍是一个谜。然而，这增加了该抗体在预测低度非肠型鼻窦腺癌亚组更好临床结局方面有用性的可能性。可能需要检查更多形态学表现相似的病例的TTF-1免疫反应性并进行临床随访以确立这一理论。
