Heffner D K, Hyams V J, Hauck K W, Lingeman C
Cancer. 1982 Jul 15;50(2):312-22. doi: 10.1002/1097-0142(19820715)50:2<312::aid-cncr2820500225>3.0.co;2-z.
The pathologic features and the behavior of 50 cases of adenocarcinoma (excluding adenoid cystic carcinoma and mucoepidermoid carcinoma) of the sinonasal tract are presented. The cases were divided on histologic grounds into 23 low-grade and 27 high-grade neoplasms. The low grade lesions had a well developed glandular pattern throughout, very uniform nuclei, and minimal mitotic activity. The high grade tumors had a less uniform glandular pattern, commonly with solid or sheet-like areas, manifested nuclear pleomorphism, and generally had a higher mitotic rate. The low-grade group had a prognosis markedly better than the high-grade group. Since the literature tends to consider all sinonasal adenocarcinomas as relentlessly progressive neoplasms with poor prognosis, it is important to recognize this category of low grade neoplasm in order that treatment and prognostication can be better related to their behavior.
本文呈现了50例鼻窦腺癌（不包括腺样囊性癌和黏液表皮样癌）的病理特征及生物学行为。根据组织学依据，这些病例被分为23例低级别和27例高级别肿瘤。低级别病变整体具有发育良好的腺管结构，细胞核非常均匀，有丝分裂活性极低。高级别肿瘤的腺管结构较不均匀，常见实性或片状区域，表现出核多形性，且通常有较高的有丝分裂率。低级别组的预后明显优于高级别组。鉴于文献倾向于将所有鼻窦腺癌视为预后不良、进展迅速的肿瘤，认识到这类低级别肿瘤很重要，以便治疗和预后评估能更好地与其生物学行为相关联。
