日本丙型肝炎病毒基因组的分子结构。
Molecular structure of the Japanese hepatitis C viral genome.
作者信息
Kato N, Hijikata M, Nakagawa M, Ootsuyama Y, Muraiso K, Ohkoshi S, Shimotohno K
机构信息
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
出版信息
FEBS Lett. 1991 Mar 25;280(2):325-8. doi: 10.1016/0014-5793(91)80322-t.
The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524-9528) indicated that this virus is a member of a new class of positive-stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin-like serine proteinase, NTPase and RNA-dependent RNA polymerase.
从日本丙型肝炎病毒基因组核苷酸序列推导的多聚蛋白氨基酸序列（N. 加藤等人（1990年）《美国国家科学院院刊》87卷，9524 - 9528页）表明，该病毒是一类新型正链RNA病毒的成员。该多聚蛋白的几个结构域还与黄病毒属和瘟病毒属的结构域显示出微弱的同源性，包括类胰凝乳蛋白酶丝氨酸蛋白酶、NTP酶和RNA依赖的RNA聚合酶。
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