Sitthidet Chayada, Stevens Joanne M, Chantratita Narisara, Currie Bart J, Peacock Sharon J, Korbsrisate Sunee, Stevens Mark P
Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Pran-nok Road, Bangkoknoi, Bangkok 10700, Thailand.
J Clin Microbiol. 2008 Jul;46(7):2418-22. doi: 10.1128/JCM.00368-08. Epub 2008 May 21.
Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bimA regions.
类鼻疽病原体伯克霍尔德菌(Burkholderia pseudomallei)基于肌动蛋白的运动需要BimA。我们报告了来自流行地区的99株伯克霍尔德菌分离株中bimA的高度保守性。伯克霍尔德菌分离株的一个地理上受限的亚群携带类鼻疽杆菌样bimA等位基因(12.1%),这使得基于物种特异性bimA区域扩增的鉴别诊断测试变得复杂。