抗突变型瓜氨酸波形蛋白抗体在类风湿关节炎诊断中的价值。

Value of anti-mutated citrullinated vimentin antibodies in diagnosing rheumatoid arthritis.

作者信息

Sghiri Rim, Bouajina Elyes, Bargaoui Dhaker, Harzallah Latifa, Fredj Hosni Ben, Sammoud Samar, Ghedira Ibtissem

机构信息

Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia.

出版信息

Rheumatol Int. 2008 Nov;29(1):59-62. doi: 10.1007/s00296-008-0614-8. Epub 2008 May 22.

DOI:10.1007/s00296-008-0614-8

PMID:18496693

Abstract

We assessed the diagnostic value of anti-mutated citrullinated vimentin antibodies (anti-MCV) and compared it with those of anti-cyclic citrullinated peptide antibodies (anti-CCP), IgA (ARF), IgM (MRF) and IgG (GRF) rheumatoid factors for rheumatoid arthritis (RA). Serum samples of 170 RA patients, with early and established RA, and 309 controls were tested for anti-MCV, anti-CCP, ARF, MRF and GRF using commercially available ELISA kits. Cut off of different tests was determined with ROC curves. The sensitivity and the specificity of anti-MCV were 74.1 and 79%, respectively. Sixty-five of 309 (21%) controls were anti-MCV positive. Sensitivity and specificity of anti-CCP were 72.4 and 96.1%, respectively. Only 12 of 309 (3.9%) controls were anti-CCP positive. Sensitivity of ARF, MRF and GRF were 64.1, 65.9 and 68.2%, respectively. Their specificity was 79.6, 74.4 and 68.9%, respectively. No significant association was observed between the antibodies tested and extrarticular manifestations. Anti-MCV shows comparable sensitivity but lower specificity than that of anti-CCP. They do not appear to be very useful in the diagnosis of RA.

摘要

我们评估了抗突变瓜氨酸波形蛋白抗体（anti-MCV）的诊断价值，并将其与抗环瓜氨酸肽抗体（anti-CCP）、IgA类风湿因子（ARF）、IgM类风湿因子（MRF）和IgG类风湿因子（GRF）在类风湿关节炎（RA）诊断中的价值进行比较。使用市售ELISA试剂盒对170例早期和确诊的RA患者以及309例对照的血清样本进行anti-MCV、anti-CCP、ARF、MRF和GRF检测。通过ROC曲线确定不同检测的临界值。anti-MCV的敏感性和特异性分别为74.1%和79%。309例对照中有65例（21%）anti-MCV呈阳性。anti-CCP的敏感性和特异性分别为72.4%和96.1%。309例对照中只有12例（3.9%）anti-CCP呈阳性。ARF、MRF和GRF的敏感性分别为64.1%、65.9%和68.2%。它们各自的特异性分别为79.6%、74.4%和68.9%。在所检测的抗体与关节外表现之间未观察到显著关联。anti-MCV显示出与anti-CCP相当的敏感性，但特异性较低。它们在RA诊断中似乎不太有用。