Sghiri Rim, Bouagina Elyes, Zaglaoui Hela, Mestiri Hajer, Harzallah Latifa, Harrabi Imed, Ghannouchi Mehdi, Mokhtar Faycel, Ghedira Ibtissem
Laboratory of Immunology, Farhat Hached Hospital, Sousse, Tunisia.
Rheumatol Int. 2007 Oct;27(12):1125-30. doi: 10.1007/s00296-007-0351-4. Epub 2007 Apr 20.
To evaluate the rheumatoid arthritis (RA) diagnostic performances of anti-cyclic citrullinated peptide antibodies (anti-CCP). Anti-CCP was detected by an enzyme linked immunosorbent assay in 164 patients with RA and 343 controls. In addition, anti-CCP predictive value for radiological damage were investigated in 37 recent-onset RA patients followed up prospectively for 2 years. Radiological damages were assessed by Sharp method modified by van der Heijde. The sensitivity of anti-CCP was 78.7% and the specificity was 95.6%. The positive predictive value and the negative predictive value were 90.2% and 90.3%, respectively. Anti-CCP were detected in sera of 79.3% of patients with recent onset RA and 78.3% of patients with long disease duration. In univariate and multivariate analyses, anti-CCP were not predictive for radiological damage. Our study confirms the high diagnostic performances of anti-CCP in RA. They are very useful to aid the diagnostic of RA in clinical practice.
评估抗环瓜氨酸肽抗体（抗CCP）对类风湿关节炎（RA）的诊断效能。采用酶联免疫吸附试验检测164例RA患者和343例对照者的抗CCP。此外，对37例近期发病的RA患者进行前瞻性随访2年，研究抗CCP对放射学损伤的预测价值。采用van der Heijde改良的Sharp方法评估放射学损伤。抗CCP的敏感性为78.7%，特异性为95.6%。阳性预测值和阴性预测值分别为90.2%和90.3%。近期发病的RA患者血清中抗CCP的检出率为79.3%，病程较长的患者为78.3%。在单因素和多因素分析中，抗CCP对放射学损伤无预测作用。我们的研究证实了抗CCP在RA中具有较高的诊断效能。它们在临床实践中对辅助RA的诊断非常有用。
