Dieckmann K P, Kreuser E D
Urologische Klinik, Freie Universität Berlin.
Urologe A. 1991 Jan;30(1):45-55.
With the advent of modern chemotherapy the dismal prognosis of disseminated germ cell tumors has changed, and there is now an overall survival rate of 90%. This review gives an overview of the historical development of chemotherapy of germ cell cancer. The stage-specific indications for chemotherapy in the management of germ cell tumors are outlined. The standard regimen is the combination of cisplatin, etoposide, and bleomycin, which is given in three to four cycles for inductive therapy and in two cycles as adjuvant therapy. Carboplatin is very active in the management of advanced seminoma, and it is also given in high-dose regimes during salvage therapy for relapses. Ifosfamide is a second-line drug and is indicated in the treatment of relapses and marker-positive residual tumors.
随着现代化疗的出现，播散性生殖细胞肿瘤的预后已得到改善，如今总体生存率达90%。本文综述了生殖细胞癌化疗的历史发展。概述了生殖细胞肿瘤治疗中化疗的分期特异性指征。标准方案是顺铂、依托泊苷和博来霉素联合使用，诱导治疗给予三至四个周期，辅助治疗给予两个周期。卡铂在晚期精原细胞瘤的治疗中活性很高，在复发的挽救治疗中也采用高剂量方案给药。异环磷酰胺是二线药物，用于复发和标记物阳性残留肿瘤的治疗。
