神经调节蛋白的作用机制。
Mechanisms of neuregulin action.
作者信息
Talmage David A
机构信息
Institute of Human Nutrition and Department of Pediatrics, Columbia University Medical Center, 630 West 168th Street, New York, NY 10024, USA.
出版信息
Novartis Found Symp. 2008;289:74-84; discussion 84-93. doi: 10.1002/9780470751251.ch6.
Abstract
Neuregulin 1 (Nrg1) and ErbB receptor tyrosine kinase signalling is essential for the formation and proper functioning of multiple organ systems and inappropriate Nrgl/ErbB signalling severely compromises health, contributing to such diverse pathologies as cancer and neuropsychiatric disorders. Numerous genetic modelling studies in mice demonstrate that Nrg1 signalling is important in the development of normal neuronal connectivity. Recent studies have identified novel signalling mechanisms and revealed unexpected roles of Nrg1 isoforms in both the developing and adult nervous system. Of particular interest to this discussion are findings linking deficits in Nrg1-ErbB4 signalling to perturbations of synaptic transmission, myelination, and the survival of particular sets of neurons and glia.
摘要
神经调节蛋白1（Nrg1）与表皮生长因子受体（ErbB）酪氨酸激酶信号传导对于多个器官系统的形成和正常功能至关重要，而不适当的Nrg1/ErbB信号传导会严重损害健康，导致癌症和神经精神疾病等多种病理状况。在小鼠中进行的大量基因建模研究表明，Nrg1信号传导在正常神经元连接的发育中很重要。最近的研究已经确定了新的信号传导机制，并揭示了Nrg1亚型在发育中和成年神经系统中的意外作用。在本次讨论中，特别值得关注的是将Nrg1-ErbB4信号传导缺陷与突触传递、髓鞘形成以及特定神经元和神经胶质细胞群的存活扰动联系起来的研究结果。
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