Guo Yawen, Zhang Wanchen, He Ru, Zheng Chuanming, Liu Xuefeng, Ge Minghua, Xu Jiajie
Department of Head and Neck Surgery, Otolaryngology & Head and Neck Center, Cancer Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Front Surg. 2022 Apr 26;9:877206. doi: 10.3389/fsurg.2022.877206. eCollection 2022.
The extent of surgical treatment for most patients with thyroid cancer (TC) remains controversial and varies widely. As an emerging technology, genetic testing facilitates tumor typing and disease progression monitoring and is expected to influence the choice of surgical approach for patients with TC. Recent genome-wide association studies (GWASs) have identified that rs2439302 (8p12) variants near NRG1 are associated with TC risk; however, the results remain inconclusive. Therefore, we aimed to perform a meta-analysis to clarify the association between rs2439302 variants and the risk of TC.
We search eligible studies using Pubmed, Scopus, Embase, Web of Science, and Cochrane library by July 2021. We analyzed the pooled OR and the corresponding 95% confidence interval (95% CI) of the included studies and then conducted subgroup analysis according to the ethnicity. We also performed a sensitivity analysis to validate the findings.
This meta-analysis finally included 7 studies involving 6,090 cases and 14,461 controls. Results showed that the G allele of the rs2439302 polymorphism was a significant risk factor of TC in Allele (G/C), Dominant (GG+GC/CC), Recessive (GG/GC+CC), Homozygote (GG/CC), Heterozygote (GC/CC) models, with pooled ORs of 1.38 (95%CI, 1.31-1.45), 1.51 (95%CI, 1.41-1.62), 1.52 (95%CI, 1.40-1.66), 1.90 (95%CI, 1.71-2.10), and 1.40 (95%CI, 1.30-1.51), respectively. The subgroup analysis showed that rs2439302 polymorphism was associated with higher TC risk in different ethnicities with OR > 1. The sensitivity analysis exhibited that the results were stable by omitting any included studies.
The study revealed that rs2439302 variants were associated with higher TC risk and may have a major influence on the choice of operative approach for patients with TC.
大多数甲状腺癌（TC）患者的手术治疗范围仍存在争议，差异很大。作为一项新兴技术，基因检测有助于肿瘤分型和疾病进展监测，并有望影响TC患者手术方式的选择。最近的全基因组关联研究（GWASs）已确定NRG1附近的rs2439302（8p12）变异与TC风险相关；然而，结果仍无定论。因此，我们旨在进行一项荟萃分析，以阐明rs2439302变异与TC风险之间的关联。
我们通过检索截至2021年7月的Pubmed、Scopus、Embase、Web of Science和Cochrane图书馆，查找符合条件的研究。我们分析了纳入研究的合并OR值和相应的95%置信区间（95%CI），然后根据种族进行亚组分析。我们还进行了敏感性分析以验证研究结果。
该荟萃分析最终纳入了7项研究，涉及6090例病例和14461例对照。结果显示，在等位基因（G/C）、显性（GG+GC/CC）、隐性（GG/GC+CC）、纯合子（GG/CC）、杂合子（GC/CC）模型中，rs2439302多态性的G等位基因是TC的显著危险因素，合并OR值分别为1.38（95%CI，1.31-1.45）、1.51（95%CI，1.41-1.62）、1.52（95%CI，1.40-1.66）、1.90（95%CI，1.71-2.10）和1.40（95%CI，1.30-1.51）。亚组分析表明，rs2439302多态性在不同种族中与较高的TC风险相关，OR>1。敏感性分析表明，剔除任何一项纳入研究后结果均稳定。
该研究表明，rs2439302变异与较高的TC风险相关，可能对TC患者手术方式的选择有重大影响。
