Wojnicki F H E, Charny G, Corwin R L W
The Pennsylvania State University, College of Health and Human Development, Nutritional Sciences Department, 126 S. Henderson, University Park, PA 16802, USA.
Physiol Behav. 2008 Jul 5;94(4):627-9. doi: 10.1016/j.physbeh.2008.03.016. Epub 2008 Apr 1.
Studies from this and another laboratory involving an animal model of binge-type behavior have used vegetable shortening containing trans-fats. Due to reformulations by vegetable shortening manufacturers to remove trans-fats from their products, only trans-fat-free shortenings are now available. The goal of the present study was to assess binge-type behavior in rats with trans-fat and trans-free vegetable shortening. Trans-fat-free shortening was provided to three different groups of non-food-deprived male Sprague Dawley rats on different schedules of access: continuous access (24 h/day-7 days/week), daily access (1 h every day), and intermittent access (1 h on Mondays, Wednesdays, Fridays). Trans-fat shortening was provided to a fourth group on the intermittent access schedule. A fifth group had no shortening access (chow only). Both intermittent groups (trans-fat-free and trans-fat) consumed significantly more shortening during the 1-h period of availability than did the daily group, and there was no difference in shortening intakes between the intermittent groups. These results are identical to previous reports of binge-type behavior in rats using this model. Thus, binge-type behavior in the present behavioral model depends upon the schedule of access, not the presence of trans-fats in the shortening.
来自本实验室及另一个实验室的、涉及暴饮暴食型行为动物模型的研究使用了含有反式脂肪的植物起酥油。由于植物起酥油制造商重新配方以从其产品中去除反式脂肪，现在仅可获得不含反式脂肪的起酥油。本研究的目的是评估喂食含反式脂肪和不含反式脂肪植物起酥油的大鼠的暴饮暴食型行为。将不含反式脂肪的起酥油以不同的获取时间表提供给三组未处于食物匮乏状态的雄性斯普拉格-道利大鼠：持续获取（每天24小时 - 每周7天）、每日获取（每天1小时）和间歇性获取（周一、周三、周五各1小时）。将含反式脂肪的起酥油以间歇性获取时间表提供给第四组。第五组不提供起酥油（仅喂食普通食物）。在1小时的可获取期间，两个间歇性获取组（不含反式脂肪和含反式脂肪）消耗的起酥油均显著多于每日获取组，并且两个间歇性获取组之间的起酥油摄入量没有差异。这些结果与之前使用该模型对大鼠暴饮暴食型行为的报道一致。因此，在当前行为模型中，暴饮暴食型行为取决于获取时间表，而非起酥油中反式脂肪的存在。
