Grønbaek Henning, Johnsen Søren P, Jepsen Peter, Gislum Mette, Vilstrup Hendrik, Tage-Jensen Ulrik, Sørensen Henrik T
Department of Medicine V, Aarhus University Hospital, Denmark.
BMC Gastroenterol. 2008 May 24;8:16. doi: 10.1186/1471-230X-8-16.
Liver diseases are suspected risk factors for intracerebral haemorrhage (ICH). We conducted a population-based case-control study to examine risk of ICH among hospitalised patients with liver cirrhosis and other liver diseases.
We used data from the hospital discharge registries (1991-2003) and the Civil Registration System in Denmark, to identify 3,522 cases of first-time hospitalisation for ICH and 35,173 sex- and age-matched population controls. Among cases and controls we identified patients with a discharge diagnosis of liver cirrhosis or other liver diseases before the date of ICH. We computed odds ratios for ICH by conditional logistic regressions, adjusting for a number of confounding factors.
There was an increased risk of ICH for patients with alcoholic liver cirrhosis (adjusted OR = 4.8, 95% CI: 2.7-8.3), non-alcoholic liver cirrhosis (adjusted OR = 7.7, 95% CI: 2.0-28.9) and non-cirrhotic alcoholic liver disease (adjusted OR = 5.4, 95%CI:3.1-9.5) but not for patients with non-cirrhotic non-alcoholic liver diseases (adjusted OR = 0.9, 95%CI:0.5-1.6). The highest risk was found among women with liver cirrhosis (OR = 8.9, 95%CI:2.9-26.7) and for patients younger than 70 years (OR = 6.1, 95%CI:3.4-10.9). There were no sex- or age-related differences in the association between other liver diseases (alcoholic or non-alcoholic) and hospitalisation with ICH.
Patients with liver cirrhosis and non-cirrhotic alcoholic liver disease have a clearly increased risk for ICH.
肝脏疾病被怀疑是脑出血（ICH）的风险因素。我们开展了一项基于人群的病例对照研究，以调查肝硬化及其他肝脏疾病住院患者发生ICH的风险。
我们使用丹麦医院出院登记处（1991 - 2003年）和民事登记系统的数据，确定了3522例首次因ICH住院的病例以及35173例性别和年龄匹配的人群对照。在病例组和对照组中，我们识别出在ICH发生日期之前出院诊断为肝硬化或其他肝脏疾病的患者。我们通过条件逻辑回归计算ICH的比值比，并对一些混杂因素进行了调整。
酒精性肝硬化患者（调整后的OR = 4.8，95%CI：2.7 - 8.3）、非酒精性肝硬化患者（调整后的OR = 7.7，95%CI：2.0 - 28.9）和非肝硬化酒精性肝病患者（调整后的OR = 5.4，95%CI：3.1 - 9.5）发生ICH的风险增加，但非肝硬化非酒精性肝病患者（调整后的OR = 0.9，95%CI：0.5 - 1.6）未增加。肝硬化女性患者（OR = 8.9，95%CI：2.9 - 26.7）和70岁以下患者（OR = 6.1，95%CI：3.4 - 10.9）的风险最高。其他肝脏疾病（酒精性或非酒精性）与ICH住院之间的关联不存在性别或年龄差异。
肝硬化和非肝硬化酒精性肝病患者发生ICH的风险明显增加。
