用甲基丙烯酸对苹婆胶进行改性以制备新型药物递送系统。
Modification of sterculia gum with methacrylic acid to prepare a novel drug delivery system.
作者信息
Singh Baljit, Sharma Nisha
机构信息
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
出版信息
Int J Biol Macromol. 2008 Aug 15;43(2):142-50. doi: 10.1016/j.ijbiomac.2008.04.008. Epub 2008 Apr 16.
The present paper deals with the modification of the sterculia gum with methacrylic acid (MAAc) to hydrogels for use in drug delivery. The hydrogels were characterized by SEMs, FTIR and swelling studies. The release dynamics of model anti-ulcer drug (ranitidine hydrochloride) from the hydrogels has been studied for the evaluation of the release mechanism. The values of the diffusion exponent 'n' (0.55, 0.54 and 0.59) and gel characteristic constant 'k' (2.109 x 10(-2), 3.698 x 10(-2) and 2.427 x 10(-2)) have been obtained, respectively, in distilled water, pH 2.2 buffer and pH 7.4 buffer. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism.
本文探讨了用甲基丙烯酸（MAAc）将苹婆胶改性为水凝胶用于药物递送。通过扫描电子显微镜（SEMs）、傅里叶变换红外光谱（FTIR）和溶胀研究对水凝胶进行了表征。研究了模型抗溃疡药物（盐酸雷尼替丁）从水凝胶中的释放动力学，以评估释放机制。分别在蒸馏水、pH 2.2缓冲液和pH 7.4缓冲液中获得了扩散指数“n”（0.55、0.54和0.59）和凝胶特性常数“k”（2.109×10⁻²、3.698×10⁻²和2.427×10⁻²）的值。药物从水凝胶中的释放通过非菲克扩散机制发生。
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