Baghel Madhuri, Sakure Kalyani, Giri Tapan Kumar, Maiti Sabyasachi, Nakhate Kartik T, Ojha Shreesh, Sharma Charu, Agrawal Yogeeta, Goyal Sameer, Badwaik Hemant
Department of Pharmaceutical Chemistry, Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Junwani, Bhilai 490020, Chhattisgarh, India.
Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences and Research, Kurud Road, Kohka, Bhilai 490024, Chhattisgarh, India.
Pharmaceuticals (Basel). 2023 May 22;16(5):776. doi: 10.3390/ph16050776.
Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured synthetics because of their intrinsic physicochemical characteristics. Studies showed that the carboxymethylation of polysaccharides considerably increases the aqueous solubility and bioactivities of inherent polysaccharides and offers structural diversity, but it also has some limitations that can be resolved by derivatization or the grafting of carboxymethylated gums. The swelling ratio, flocculation capacity, viscosity, partition coefficient, metal absorption properties, and thermosensitivity of natural polysaccharides have been improved as a result of these changes. In order to create better and functionally enhanced polysaccharides, researchers have modified the structures and properties of carboxymethylated gums. This review summarizes the various ways of modifying carboxymethylated gums, explores the impact that molecular modifications have on their physicochemical characteristics and bioactivities, and sheds light on various applications for the derivatives of carboxymethylated polysaccharides.
天然多糖已在药物递送和组织工程研究中得到广泛应用。它们具有出色的生物相容性且副作用较少；然而，由于其固有的物理化学特性，评估它们与人工合成材料的生物活性具有挑战性。研究表明，多糖的羧甲基化显著提高了天然多糖的水溶性和生物活性，并提供了结构多样性，但它也存在一些局限性，可通过衍生化或羧甲基化胶的接枝来解决。这些变化提高了天然多糖的溶胀率、絮凝能力、粘度、分配系数、金属吸附性能和热敏性。为了制备性能更优、功能更强的多糖，研究人员对羧甲基化胶的结构和性能进行了修饰。本文综述了修饰羧甲基化胶的各种方法，探讨了分子修饰对其物理化学特性和生物活性的影响，并阐明了羧甲基化多糖衍生物的各种应用。
