Duman Dursun, Palit Fatih, Simsek Ergun, Bilgehan Karadag
Haydarpasa Numune Training and Research Hospital, Department of Cardiology, Tibbiye Caddesi, Kadiköy/Istanbul, Turkey.
Eur J Heart Fail. 2008 Jun;10(6):556-9. doi: 10.1016/j.ejheart.2008.04.012. Epub 2008 May 23.
To assess the relation between serum levels of carbohydrate antigen 125 (CA 125) and parameters of left ventricular (LV) filling pressure in patients with advanced heart failure (AHF).
Forty-nine patients (mean age 67+/-10 years) with LV ejection fraction (EF) < or =0.35 and New York Heart Association (NYHA) class III or IV symptoms of heart failure were enrolled. Left atrial volume indexed to body surface area (LAVI) and the ratio of mitral inflow early diastolic velocity to annulus velocity (E/e) were evaluated with pulsed wave and tissue Doppler. Plasma B-type natriuretic peptide (BNP) was also measured.
The median overall CA 125 value was 44.0 (17.7-140) U/ml. CA 125 above the normal value (<35 U/ml) was found in 28 of the 49 patients (57%). Compared to patients with normal CA 125 levels, those with elevated CA 125 had a higher NYHA class and increased serum BNP levels, LAVI and E/e. In multivariate analysis, serum CA 125 levels were significantly associated with BNP (standardized beta coefficient=0.58, p<0.001) and LAVI (standardized beta coefficient 0.34, p<0.005).
Our study demonstrates that elevated serum CA 125 levels are associated with increased LAVI in parallel to increased neurohormonal activation in patients with AHF.
评估晚期心力衰竭（AHF）患者血清糖类抗原125（CA 125）水平与左心室（LV）充盈压参数之间的关系。
纳入49例左心室射血分数（EF）≤0.35且纽约心脏协会（NYHA）心功能分级为III或IV级的心力衰竭患者（平均年龄67±10岁）。采用脉冲波和组织多普勒评估体表面积指数化左心房容积（LAVI）以及二尖瓣舒张早期血流速度与瓣环速度之比（E/e）。同时检测血浆B型利钠肽（BNP）。
CA 125总体中位数为44.0（17.7 - 140）U/ml。49例患者中有28例（57%）CA 125高于正常值（<35 U/ml）。与CA 125水平正常的患者相比，CA 125升高的患者NYHA分级更高，血清BNP水平、LAVI和E/e也更高。多因素分析显示，血清CA 125水平与BNP（标准化β系数 = 0.58，p<0.001）和LAVI（标准化β系数0.34，p<0.005）显著相关。
我们的研究表明，AHF患者血清CA 125水平升高与LAVI增加相关，同时伴有神经激素激活增加。
